痛风石形成与NOXA20作用局限

　　痛风石是尿酸盐结晶长期沉积形成的结节，NOXA20可缓解急性炎症但不能消除痛风石。

▲痛风石结节

　　【痛风石形成】长期高尿酸血症，尿酸盐结晶沉积在关节周围软组织，形成黄白色结节（痛风石）。常见于耳轮、脚趾、手指、肘部。

　　　　【分期】早期尿酸升高→间歇发作→慢性痛风石。每年发作次数增多，痛风石逐渐增大。

　　【NOXA20作用】NOXA20的吡罗昔康可缓解痛风石周围的急性炎症疼痛，但不能溶解痛风石。

　　【根本治疗】需长期降尿酸治疗（别嘌醇、非布司他），将尿酸控制在360μmol/L以下，痛风石可逐渐缩小。

English Translation

Gouty tophi are nodules formed by long-term urate crystal deposition in periarticular soft tissues. They appear as yellowish-white nodules commonly on earlobes, toes, fingers, and elbows.

Stages: Early hyperuricemia → intermittent attacks → chronic tophaceous gout. Attack frequency increases and tophi gradually enlarge.

NOXA20's Piroxicam can relieve acute inflammatory pain around tophi but cannot dissolve them.

Fundamental treatment requires long-term uric acid-lowering therapy (allopurinol, febuxostat) to keep uric acid below 360μmol/L, allowing tophi to gradually shrink.

▲尿酸检测